您可以利用括号内的隐式行连接（如PEP-8中推荐的）：

for (param_one, param_two, 
     param_three, param_four, 
     param_five) in get_params(some_stuff_here, 
                               and_another stuff):

（显然，您可以选择每行的长度以及是否需要在每组括号中包括换行符。）
8+年后再看这篇文章，我会在一开始就把长长的单条逻辑线拆开，而不是试图把整个东西拆成多条物理线，例如（很像@poke所做的），

for t in get_params(some_stuff_here,
                    and_other_stuff):
    (param_one,
     param_two,
     param_three,
     param_four, param_five) = t

all_params = get_params(some_stuff_here, and_another_stuff)
for param_one, param_two, param_three, param_four, param_five in all_params:
    pass

或者你可以在循环中移动目标列表：

for params in get_params(some_stuff_here, and_another_stuff):
    param_one, param_two, param_three, param_four, param_five = params
    pass

或者合并。