我可能会探索海象操作符来清理这个问题，我真的不知道这是否会“足够快”。这个想法是读到你想要的点。读/打印要删除的东西，然后读剩下的：

line_to_delete = 2
with open("in.txt", "rt") as file_in:
    with open("out.txt", "wt") as file_out:
        file_out.write(file_in.read(15 * (line_to_delete -1)))
        print(file_in.read(15))
        file_out.write(file_in.read())

我认为这可能会占用大量内存，因此您可以通过执行以下操作来生成更流畅的结果：

line_to_delete = 2

with open("in.txt", "rt") as file_in:
    current_line = 1
    with open("out.txt", "wt") as file_out:
        while True:
            line = file_in.read(15)
            if not line:
                break

            if current_line == line_to_delete:
                print(line)
            else:
                file_out.write(line)

            current_line += 1

打印BBBBBBBBBBBBBB.并生成如下文件：

AAAAAAAAAAAAAA.CCCCCCCCCCCCCC.DDDDDDDDDDDDDD.EEEEEEEEEEEEEE.FFFFFFFFFFFFFF.GGGGGGGGGGGGGG.HHHHHHHHHHHHHH.IIIIIIIIIIIIII.JJJJJJJJJJJJJJ.KKKKKKKKKKKKKK.