还有另一个类似的问题和答案（https://stackoverflow.com/a/17367570/3063884），其中的解决方案是避免使用双点表示法，而是为沿着使用的每个对象定义变量，并分别对每个对象使用Marshal.ReleaseComObject。
直接从链接的解决方案复制：

var workbook = excel.Workbooks.Open(/*params*/)

---〉改为使用--〉

var workbooks = excel.Workbooks;
var workbook = workbooks.Open(/*params*/)

然后，完成后，释放每个COM对象：

Marshal.ReleaseComObject(workbook);
Marshal.ReleaseComObject(workbooks);
Marshal.ReleaseComObject(excel);

很长一段时间没有答案，但对我有效的是调用GC.Collect（）;从呼叫者，
即代替

main()
{
    ...
    doexcelstuff();
    ...
}

void doexcelstuff()
{
    Excel.Application ExApp2 = new Excel.Application();
    Excel.Workbook excelWb = ExApp2 .Workbooks.Open(excelFName);
    Excel._Worksheet excelWorksheet = excelWb.Sheets[excelSName];
    //...
    excelWb.Close();
    ExApp2.Quit();     
    Marshal.ReleaseComObject(excelWb);
    Marshal.ReleaseComObject(excelWorksheet);
    Marshal.ReleaseComObject(ExApp2);
    excelWb = null;
    excelWorksheet= null;
    ExApp2= null;
    GC.Collect();
}

使用以上Excel不会死

但是一个非常小的变化，从哪里调用GC

main()
{
    ...
    doexcelstuff();
    GC.Collect();      // <<-- moved the GC to here (the caller)
    ...
}

void doexcelstuff()
{
    Excel.Application ExApp2 = new Excel.Application();
    Excel.Workbook excelWb = ExApp2 .Workbooks.Open(excelFName);
    Excel._Worksheet excelWorksheet = excelWb.Sheets[excelSName];
    //...
    excelWb.Close();
    ExApp2.Quit();     
    Marshal.ReleaseComObject(excelWb);
    Marshal.ReleaseComObject(excelWorksheet);
    Marshal.ReleaseComObject(ExApp2);
    excelWb = null;
    excelWorksheet= null;
    ExApp2= null;
    // removed the GC from here
}

我猜垃圾收集器还需要悄悄地从堆中清理内部创建的临时值（包括引用/指针）--在本例中，我猜其中一些临时值指向COM对象。
(Just需要对机器在源代码下如何工作有一点了解。）

您没有关闭工作簿。请关闭工作簿，然后在退出Excel应用程序之前将其释放：

excelWorkbook.close();
Marshal.ReleaseComObject(excelWorkbook);
ExcelApp.Quit();

对我来说，这很有效！

//Initializing
Application excelApp = new Application();
Workbook excelWorkbook = excelApp.Workbooks.Open(pathExcelFile, 0, true, 5, "", "", 
                               true, XlPlatform.xlWindows, "\t", false, false, 0, 
                               true, 1, 0);
Worksheet excelWorksheet = (Worksheet)excelWorkbook.Sheets[1];

//closing
excelWorksheet = null;

excelWorkbook.Close();
excelWorkbook = null;

excelApp.Quit();
excelApp = null;

Interop是出了名的bug...我在保存工作簿后使用以下方法，并且在退出应用程序时不再有Excel保持打开状态的问题：

while (Marshal.ReleaseComObject(wb) > 0);
while (Marshal.ReleaseComObject(xl) > 0);

wb = null;
xl = null;

GC.WaitForPendingFinalizers();
GC.Collect();
GC.WaitForPendingFinalizers();
GC.Collect();

wb是我的工作簿对象，xl是我的Excel.Application对象。

对我来说，这很管用：//opening

var excelFile = new Application();
        Workbook workBook1 = excelFile.Workbooks.Open(goldenCopy_path);
        Workbook workBook2 = excelFile.Workbooks.Open(new_path);

        Worksheet goldWorkSheet, newWorkSheet;
        goldWorkSheet = workBook1.Worksheets[1];
        newWorkSheet = workBook2.Worksheets[1];

//关闭//它将从VisualStudio中释放工作簿

goldWorkSheet = null;
        newWorkSheet = null;

        workBook1.Close();
        workBook2.Close();
        workBook1 = null;
        workBook2 = null;

        excelFile.Quit();
        excelFile = null;

这个代码对我起作用了。

Excel.Application excelApp = null;
        Excel.Workbooks excelWorkbooks = null;
        Excel.Workbook excelWorkbook = null;
        Excel._Worksheet xlWorkSheet = null;
        Excel.Range range = null;

        excelApp = new Excel.Application();
        excelWorkbooks = excelApp.Workbooks;
        excelWorkbook = excelWorkbooks.Open(excelName);
        xlWorkSheet = (Excel.Worksheet)excelWorkbook.ActiveSheet;

        range = xlWorkSheet.Range["C3"] ;
        range.Value = "Update Data";
        Marshal.ReleaseComObject(range);

        xlWorkSheet.SaveAs(path);
            
        Marshal.ReleaseComObject(xlWorkSheet);
        excelWorkbook.Close();
        Marshal.ReleaseComObject(excelWorkbook);
        excelWorkbooks.Close();
        Marshal.ReleaseComObject(excelWorkbooks);
        excelApp.Quit();
        Marshal.ReleaseComObject(excelApp);

var Process = Process.GetProcessesByName("excel").Select(x => x.Id.ToString());
Application ExcelApp = new Excel.Application();
Workbook excelWorkbook = ExcelApp2.Workbooks.Open(excelFileNamePath);
_Worksheet excelWorksheet = excelWorkbook.Sheets[excelSheetName];
Range excelRange = excelWorksheet.UsedRange;
//...for loops for reading data
foreach (Process pros in Process.GetProcessesByName("excel"))
{
    if (!array1.Contains(pros.Id.ToString()))
    {
        Console.WriteLine(pros.Id.ToString());
        pros.Kill();

    }

}