最好的办法是通过内省脚本运行的系统，并对使用哪种整型进行最佳选择。

if sys.platform == 'win32':
    time_t = ctypes.c_uint64
# ...

底线是time_t没有在标准中定义。这取决于操作系统和编译器。所以你在Python脚本中对time_t的定义取决于你正在与之交互的DLL/。

从Python 3.12开始（撰写本文时仍在开发中，计划于2023年10月发布），ctypes.c_time_t可以用于此，在您的示例中：

# This requires Python 3.12, which adds ctypes.c_time_t

from ctypes import *

class MyStruct(Structure):
    _fields_ = [
        ('timestamp', c_time_t),
        ('code', c_int16),
    ]

我有一个last year的用例，the patch被接受了。
如果你还没有Python 3.12，像这样的东西可以做到这一点，尽管它没有涵盖所有情况（从上面的PR/issue）：

import platform
import ctypes

if platform.system() == 'Windows':
    # Assume MSVC(?) - what about mingw/clang?
    time_t = ctypes.c_int64
elif ctypes.sizeof(ctypes.c_void_p) == ctypes.sizeof(ctypes.c_int64):
    # 64-bit platform of any kind - assume 64-bit time_t(?)
    time_t = ctypes.c_int64
else:
    # assume some kind of 32-bit platform(?)
    time_t = ctypes.c_int32

# ... use time_t here ...

这对于Windows（MSVC〉= 2005），macOS（x86_64，aarch 64）和Linux（arm 32，aarch 64，x86，x86_64）应该没问题，但可能需要在某些CPU上调整BSD。
一旦Python 3.12发布并且ctypes.c_time_t是一个东西，你就可以使用它了。
例如，这是gPodder的libgpod_ctypes.py如何尝试使用ctypes.c_time_t，但在旧系统上福尔斯了一些简单的启发式方法：

# ctypes.c_time_t will be available in Python 3.12 onwards
# See also: https://github.com/python/cpython/pull/92870
if hasattr(ctypes, 'c_time_t'):
    time_t = ctypes.c_time_t
else:
    # See also: https://github.com/python/cpython/issues/92869
    if ctypes.sizeof(ctypes.c_void_p) == ctypes.sizeof(ctypes.c_int64):
        time_t = ctypes.c_int64
    else:
        # On 32-bit systems, time_t is historically 32-bit, but due to Y2K38
        # there have been efforts to establish 64-bit time_t on 32-bit Linux:
        # https://linux.slashdot.org/story/20/02/15/0247201/linux-is-ready-for-the-end-of-time
        # https://www.gnu.org/software/libc/manual/html_node/64_002dbit-time-symbol-handling.html
        time_t = ctypes.c_int32