您应该安装MySQL的.NET驱动程序。然后安装SQLprovider。文档中有MySQL的示例。你可以连接到数据库并像这样查询它：

type sql = SqlDataProvider<
                dbVendor,
                connString,
                ResolutionPath = resPath,
                IndividualsAmount = indivAmount,
                UseOptionTypes = useOptTypes,
                Owner = "HR"
            >
let ctx = sql.GetDataContext()

let employees = 
    ctx.Hr.Employees 
    |> Seq.map (fun e -> e.ColumnValues |> Seq.toList)
    |> Seq.toList

connstring将是这样的：

[<Literal>]
let connString  = "Server=localhost;Database=HR;User=root;Password=password"

您还应该阅读https://msdn.microsoft.com/visualfsharpdocs/conceptual/walkthrough-accessing-a-sql-database-by-using-type-providers-%5bfsharp%5d

我也会说SQLProvider是一种方法，因为这样你就可以根据你的数据库验证你的逻辑，如果你的数据库发生了变化，你就会注意到。
但是，如果您需要，可以手动连接：

// Reference Nuget package MySql.Data
//#r @"./../packages/MySql.Data/lib/net40/MySql.Data.dll"

open System
open MySql.Data.MySqlClient

let cstr = "server = localhost; database = myDatabase; uid = username;pwd = password"

let ExecuteSqlAsync (query : string) parameters =
  use rawSqlConnection = new MySqlConnection(cstr)
  async {
    do! rawSqlConnection.OpenAsync() |> Async.AwaitIAsyncResult |> Async.Ignore
    use command = new MySqlCommand(query, rawSqlConnection)
    parameters |> List.iter(fun (par:string*string) -> command.Parameters.AddWithValue(par) |> ignore)
    let! affectedRows = command.ExecuteNonQueryAsync() |> Async.AwaitTask
    match affectedRows with
    | 0 -> "ExecuteSql 0 rows affected: " + query |> Console.WriteLine
           ()
    | x -> ()
  }

let ExecuteSql (query : string) parameters =
    use rawSqlConnection = new MySqlConnection(cstr)
    rawSqlConnection.Open()
    use command = new MySqlCommand(query, rawSqlConnection)
    parameters |> List.iter(fun (par:string*string) -> command.Parameters.AddWithValue(par) |> ignore)
    let affectedRows = command.ExecuteNonQuery()
    match affectedRows with
    | 0 -> "ExecuteSql 0 rows affected: " + query |> Console.WriteLine
           ()
    | x -> ()