这也发生在我身上。当我从睡眠中唤醒我的电脑时会发生这种情况。两台完全相同的显示器，但配置不同的fancyzones,它们在唤醒后大部分时间都会交换配置。这只是从Windows 10升级到Windows 11后才开始发生的。AMD显卡。可能这不是一个fancyzones的bug,但感觉相关：在Windows 11升级后，从睡眠中唤醒有时需要10秒，大约20%的时间一台显示器被禁用，另一台显示器分辨率极低。

I have a similar experience to both @MontanaIrish and more closely to how @madelynnw described it. I have a newish machine with integrated Intel graphics card, and it has always been on W11, and have two matching monitors. My FancyZone layouts get swapped or mirrored after wake up from sleep. This was not the experience I had on my old machine with W10. I honestly forget if it has always been misbehaving from first install on this new W11 machine or if was working as expected (set it and forget it) in the beginning and now is faulty.
If I set my left (primary / "3") screen to a grid of 4 FZs, and my right (secondary / "2") screen to a very customized "dashboard" layout in the morning, when I wake it back up after going to lunch or stepping away for a bit, I will have them both set as the "dashboard" layout or sometime then will flip-flop and the grid is on "2" and the dashboard is on "3". This is pretty consistent after wake, whether it is for 30 minutes or overnight (I do not turn off the desktop overnight).
"3" and "2" is referring to how Windows identifies them in the Display Settings pane of Windows Settings. I have a third monitor plugged in that is marked as "disconnect this display" in the layout section for mirroring or extending. I notice when I wake my computer, that Screen 2 wakes up itself a bit before Screen 3, based on when the On Screen Display of the monitor itself appears for each (it shows the connection interface that is active - HDMI).
Windows 11 Pro - fully updated
Intel NUC13 - integrated graphics
Admin user
Admin PowerToys - fully updated, has been happening for a number of versions now

我也遇到了同样的问题，双显示器，每个屏幕设置了布局，并且应用程序设置在对应的网格内。锁屏登录或者第二天早上登录后，发现副屏的应用程序都跑到了主屏上，需要重新拖拽到副屏上。我用的Windows 10。